Risk factors for the development of Fistulae and Stenoses in Crohn Disease patients in the Swiss Inflammatory Bowel Disease Cohort

Détails

Ressource 1Télécharger: post-print Fournier_cover.pdf (2705.08 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_45DC0ECE295B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Risk factors for the development of Fistulae and Stenoses in Crohn Disease patients in the Swiss Inflammatory Bowel Disease Cohort
Périodique
Inflammatory Intestinal Diseases
Auteur(s)
Zeitz Jonas, Fournier Nicolas, Labenz Christian, Biedermann Luc, Frei Pascal, Misselwitz Benjamin, Scharl Sylvie, Vavricka Stephan R., Sulz Michael C., Fried Michael, Rogler Gerhard, Scharl Michael
ISSN
2296-9403
2296-9365
Statut éditorial
Publié
Date de publication
2017
Volume
1
Numéro
4
Pages
172-181
Langue
anglais
Résumé
Background: Fistulae and stenoses represent frequent and severe complications in patients with Crohn disease (CD). Our study aimed to identify risk factors for fistula and stenosis formation in CD patients. Summary: We retrieved data of 1,600 CD patients from the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). The risk for fistulae and stenoses in relation to gender, age at diagnosis, smoking status at diagnosis, and ileal involvement at diagnosis were analyzed. In the multivariate analysis, female gender showed a lower risk for developing perianal and any fistula (risk ratio [RR] 0.721, 95% confidence interval [CI] 0.582-0.893, p = 0.003 and RR 0.717, 95% CI 0.580-0.888, p = 0.002, respectively), and older age at diagnosis showed a lower risk for developing perianal fistula (RR 0.661, 95% CI 0.439-0.995, p = 0.047). Furthermore, ileal involvement was associated with a lower risk for perianal fistula (RR 0.713, 95% CI 0.561-0.906, p = 0.006), a lower risk for any fistula (RR 0.709, 95% CI 0.558-0.901, p = 0.005), and a higher risk for stenosis (RR 2.170, 95% CI 1.728-2.725, p < 0.001). Key Messages: In the nationwide SIBDCS, younger age at diagnosis and male gender were risk factors for developing perianal and nonperianal fistulae. Additionally, ileal involvement was revealed to be a potent risk factor (RR 2.170) for developing a stenosis.
Création de la notice
18/07/2017 12:12
Dernière modification de la notice
03/03/2018 16:46
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