The hemodynamic response of conscious normotensive rats to atriopeptin III: Lack of a role of the parasympathetic nervous system.

Détails

ID Serval
serval:BIB_45AD0558B3F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The hemodynamic response of conscious normotensive rats to atriopeptin III: Lack of a role of the parasympathetic nervous system.
Périodique
European Journal of Pharmacology
Auteur(s)
Waeber B., Matsueda G.R., Aubert J.F., Nussberger J., Brunner H.R.
ISSN
0014-2999
Statut éditorial
Publié
Date de publication
1986
Peer-reviewed
Oui
Volume
125
Numéro
2
Pages
177-184
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun 17
Résumé
The influence of the parasympathetic nervous system on the cardiovascular response to a synthetic atrial peptide (atriopeptin III) was examined in conscious normotensive rats by utilizing radiolabelled microspheres. Atriopeptin III was infused intravenously for 30 min at a rate of 1 microgram/min per rat in animals pretreated with a bolus intravenous injection of atropine, (150 micrograms/rat, n = 8) or of its vehicle (n = 8). Additional animals (n = 9) received the vehicle of both atropine and atriopeptin III. The atrial peptide decreased mean blood pressure to a similar extent in rats pretreated with atropine (from 124 +/- 4.5 to 108 +/- 5.3 mm Hg, mean +/- S.E.M., P less than 0.05) and in the controls (from 123 +/- 3.8 to 105 +/- 3.8 mm Hg, P less than 0.05). Heart rate rose significantly after administration of atropine. After the 30 min infusion, the cardiac index was significantly lower (P less than 0.05) in both groups infused with atriopeptin III (23.7 +/- 2.3 after atropine pretreatment and 25.1 +/- 2.2 ml X min-1 X 100 g-1 without atropine) than in the group of rats given only the vehicle of both atropine and atriopeptin III (32.4 +/- 2.8 ml X min-1 X 100 g-1). Calculated systemic vascular resistance tended to be higher in the former two groups than in the latter. There was no significant difference in regional blood flow distribution within the three groups of rats. These data therefore indicate that in conscious rats atriopeptin III reduces blood pressure and cardiac output without concomitantly diminishing total peripheral vascular resistance.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals, Atrial Natriuretic Factor, Atropine, Blood Pressure, Cardiac Output, Heart Rate, Hemodynamics, Male, Microspheres, Parasympathetic Nervous System, Rats, Rats, Inbred Strains, Regional Blood Flow
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
03/03/2018 16:46
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