Low-Frequency Blood Group Antigens in Switzerland.

Détails

ID Serval
serval:BIB_458C9886325D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Low-Frequency Blood Group Antigens in Switzerland.
Périodique
Transfusion medicine and hemotherapy
Auteur(s)
Gassner C., Degenhardt F., Meyer S., Vollmert C., Trost N., Neuenschwander K., Merki Y., Portmann C., Sigurdardottir S., Zorbas A., Engström C., Gottschalk J., Amar El Dusouqui S., Waldvogel-Abramovski S., Rigal E., Tissot J.D., Tinguely C., Mauvais S.M., Sarraj A., Bessero D., Stalder M., Infanti L., Buser A., Sigle J., Weingand T., Castelli D., Braisch M.C., Thierbach J., Heer S., Schulzki T., Krawczak M., Franke A., Frey B.M.
ISSN
1660-3796 (Print)
ISSN-L
1660-3796
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
45
Numéro
4
Pages
239-250
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested.
In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA).
326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products.
Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.
Mots-clé
Blood group allele, Blood groups, High-frequency antigen, Low-frequency antigen, Population genetics, Rare donor panel/program, Rare/molecular blood group, Switzerland
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/10/2018 22:18
Dernière modification de la notice
08/05/2019 17:54
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