Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.

Details

Serval ID
serval:BIB_451E57E39BC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
Journal
European journal of neurology
Author(s)
Gensicke H., Wicht A., Bill O., Zini A., Costa P., Kägi G., Stark R., Seiffge D.J., Traenka C., Peters N., Bonati L.H., Giovannini G., De Marchis G.M., Poli L., Polymeris A., Vanacker P., Sarikaya H., Lyrer P.A., Pezzini A., Vandelli L., Michel P., Engelter S.T.
Working group(s)
Thrombolysis in Stroke Patients (TriSP) collaborators
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
23
Number
12
Pages
1705-1712
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated.
In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m2 ) from underweight (<18.5 kg/m2 ), overweight (25-29.9 kg/m2 ) and obese (≥30 kg/m2 ) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated.
Of 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively.
In this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH.

Keywords
Aged, Aged, 80 and over, Body Mass Index, Brain Ischemia/drug therapy, Female, Humans, Infusions, Intravenous, Intracranial Hemorrhages/etiology, Male, Middle Aged, Prognosis, Risk, Stroke/drug therapy, Thrombolytic Therapy/adverse effects, Treatment Outcome, body mass index, intravenous thrombolysis, outcome, stroke, symptomatic intracranial haemorrhage
Pubmed
Web of science
Create date
04/08/2016 17:18
Last modification date
20/08/2019 13:49
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