An HMG-box-containing T-cell factor required for thymocyte differentiation.

Détails

ID Serval
serval:BIB_444D59B086F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An HMG-box-containing T-cell factor required for thymocyte differentiation.
Périodique
Nature
Auteur(s)
Verbeek S., Izon D., Hofhuis F., Robanus-Maandag E., te Riele H., van de Wetering M., Oosterwegel M., Wilson A., MacDonald H.R., Clevers H.
ISSN
0028-0836
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
374
Numéro
6517
Pages
70-74
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Two candidate genes for controlling thymocyte differentiation, T-cell factor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related DNA-binding HMG-box proteins. Their expression pattern is complex and largely overlapping during embryogenesis, yet restricted to lymphocytes postnatally. Here we generate two independent germline mutations in Tcf-1 and find that thymocyte development in (otherwise normal) mutant mice is blocked at the transition from the CD8+, immature single-positive to the CD4+/CD8+ double-positive stage. In contrast to wild-type mice, most of the immature single-positive cells in the mutants are not in the cell cycle and the number of immunocompetent T cells in peripheral lymphoid organs is reduced. We conclude that Tcf-1 controls an essential step in thymocyte differentiation.
Mots-clé
Animals, Base Sequence, Cell Cycle, Cell Differentiation, DNA, DNA-Binding Proteins/genetics, DNA-Binding Proteins/physiology, Germ-Line Mutation, Homeodomain Proteins/physiology, Immunophenotyping, Lymphocyte Count, Lymphoid Enhancer-Binding Factor 1, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Molecular Sequence Data, T Cell Transcription Factor 1, T-Lymphocytes/cytology, T-Lymphocytes/immunology, Thymus Gland/cytology, Transcription Factors/genetics, Transcription Factors/physiology
Pubmed
Web of science
Création de la notice
11/02/2010 15:20
Dernière modification de la notice
20/08/2019 13:48
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