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Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.
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Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.
Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Culture Techniques, Cell Differentiation, Cell Proliferation, Cornea, Epithelium, Corneal, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Mice, Knockout, Morphogenesis, Phenotype, Stem Cells, Time Factors, Wound Healing
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