Survival-independent function of NF-kappaB/Rel during late stages of thymocyte differentiation.

Details

Serval ID
serval:BIB_43648B6438C5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Survival-independent function of NF-kappaB/Rel during late stages of thymocyte differentiation.
Journal
Molecular immunology
Author(s)
Esslinger C.W., Jongeneel C.V., MacDonald H.R.
ISSN
0161-5890
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
35
Number
13
Pages
847-852
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Transcription factors of the NF-kappaB/Rel family are important mediators of extracellular signals. Their implication in positive selection of thymocytes is suggested by a defective thymic development in transgenic mice that over-express IkappaB in thymocytes. These mice exhibit an accumulation of an unusually prominent population of TCRhigh/CD4/CD8 double positive cells in the thymus and a dramatic reduction of CD4+ and CD8+ cells in the periphery. The present study addresses the role of NF-kappaB in survival and differentiation processes of maturing thymocytes using IkappaB/bcl-2 and IkappaB/HY double-transgenic mice. Neither the introduction of the anti-apoptosis gene bcl-2 nor the positively selecting background in female HY transgenic mice resulted in a rescue of the maturational defects observed in the thymus of IkappaB transgenic mice. Thus, rather than promoting survival the main role of NF-kappaB/Rel proteins during positive selection of thymocytes appears to be the mediation of differentiation signals.
Keywords
Animals, Antigens, CD4/metabolism, Antigens, CD8/metabolism, Cell Differentiation, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Female, Genes, bcl-2, H-Y Antigen/genetics, H-Y Antigen/metabolism, I-kappa B Proteins, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, NF-kappa B/metabolism, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-rel, Receptors, Antigen, T-Cell, alpha-beta/metabolism, Signal Transduction, T-Lymphocytes/cytology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
24/01/2008 15:39
Last modification date
20/08/2019 13:47
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