Article: article from journal or magazin.
Twenty-day cerebral and umbilical Doppler monitoring on a growth retarded and hypoxic fetus1
European Journal of Obstetrics, Gynecology, and Reproductive Biology
DA - 19961114LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov'tSB - IM
In one growth retarded and hypoxic fetus, the cerebral and umbilical hemodynamic changes were assessed (by Doppler), daily over 20 days. The fetal brain was investigated by magnetic resonance imaging (MRI) close to the delivery, and because the fetus died at delivery we performed an anatomical study of the fetal brain. The evolution of the fetal hemodynamics (day by day) was interpreted according to the MRI findings and the clinical findings. During the period of observation (under sustained hypoxia) the fetal deterioration was characterized by: (a) the progressive development of the oligohydramnios (190d), (b) the disappearance of the vascular reactivity (eight successive cerebral resistance index (RI) constant at 194d), (c) the occurrence of fetal heart rate decelerations (199d), and finally (d) the increase of the cerebral vascular resistances with reduction of the brain perfusion (204d). The anatomical study of the brain showed a periventricular congestion however the histology revealed hypoxic lesions like gliosis and a marked vasodilation of the anterior and middle cerebral arteries. Finally in addition to single Doppler measurements performed 1 week before delivery (for prediction of fetal outcome), one can suggest to use the 'loss of fluctuation of the cerebral RI' to identify the beginning of the period of very high risk for the fetus. Such hypothesis may have to be confirmed on a larger number of pathological pregnancies
Adult/Echoencephalography/Female/Fetal Growth Retardation/ultrasonography/Fetal Hypoxia/Hemodynamics/physiology/Humans/Magnetic Resonance Imaging/Pregnancy/Umbilical Cord
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