Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications.

Details

Serval ID
serval:BIB_402299F38D09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications.
Journal
Bioorganic and Medicinal Chemistry Letters
Author(s)
Passemard S., Staedler D., Učňová L., Schneiter G.S., Kong P., Bonacina L., Juillerat-Jeanneret L., Gerber-Lemaire S.
ISSN
1464-3405 (Electronic)
ISSN-L
0960-894X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
23
Number
17
Pages
5006-5010
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications.
Pubmed
Web of science
Create date
14/08/2013 11:05
Last modification date
20/10/2020 10:08
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