Effect of low dose dopamine on hemodynamic and renal function in children
Details
Serval ID
serval:BIB_400B59D30D40
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of low dose dopamine on hemodynamic and renal function in children
Journal
Pediatric Research
ISSN
0031-3998
Publication state
Published
Issued date
09/1989
Peer-reviewed
Oui
Volume
26
Number
3
Pages
200-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
The purpose of the study was to investigate the effect of low doses of dopamine in children. Fourteen cases were studied after open heart surgery. Cardiac output and renal parameters were determined under baseline conditions and under continuous infusion of dopamine 2.5 and 5 micrograms/kg/min. During the control period cardiac index was 2.62 +/- 0.19 L/min/m2, renal plasma flow was decreased at 269 +/- 41 mL/min/1.73 m2, GFR was 86.6 +/- 9.2 mL/min/1.73 m2, and filtration fraction was elevated at 37.1 +/- 1.9%. Plasma concentration of aldosterone correlated with the filtration fraction. At 5 micrograms/kg/min dopamine increased significantly cardiac output, renal plasma flow, and to a lesser extent GFR, thus decreasing the filtration fraction. At 2.5 micrograms/kg/min dopamine, increased renal plasma flow only in patients older than 5 y and had no effect on the other parameters. The increase of cardiac output in response to dopamine was abolished by propranolol pretreatment. By contrast, the hemodynamic renal response to dopamine was not altered by beta-blockade. These results indicate that 5 micrograms/kg/min of dopamine could prevent renal failure after open heart surgery in children by increasing renal blood flow and attenuating renal compensatory mechanisms.
Keywords
Adolescent
Aldosterone/blood
Cardiac Output/drug effects
Cardiac Surgical Procedures
Child
Child, Preschool
Creatinine/blood
Dopamine/*pharmacology
Female
Hemodynamic Processes/*drug effects
Humans
Infant
Kidney/*drug effects/physiology
Kidney Function Tests
Male
Propranolol/pharmacology
Regional Blood Flow
Pubmed
Web of science
Open Access
Yes
Create date
15/01/2008 15:28
Last modification date
20/08/2019 14:37