Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy
Details
Serval ID
serval:BIB_3FF45182E5CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy
Journal
Dermatology
ISSN
1018-8665 (Print)
Publication state
Published
Issued date
1999
Volume
199
Number
2
Pages
106-12
Notes
Comparative Study
Journal Article
Journal Article
Abstract
The potential carcinogenic risk of bath PUVA therapy was compared to that of systemic (oral) PUVA. An analysis of the epidemiological data on cancer risk following bath PUVA with trimethylpsoralen does not support the conclusion that bath PUVA per se is less carcinogenic than systemic PUVA with 8-methoxypsoralen (8-MOP). Pharmacokinetic studies indicate that both the concentration of 8-MOP in the target organ for PUVA carcinogenicity (skin) at the relevant time point (time point of UVA irradiation) and the extents of biological effects in the skin are comparable following bathwater or systemic 8-MOP administration. Furthermore, the therapeutic effects of PUVA arise from the same photochemical reaction mechanisms as do the carcinogenic effects. Theoretically, the ratio of (desired) cytotoxic versus (undesired) mutagenic effects could increase with increasing efficiency of the PUVA therapy itself. On the basis of the available evidence, it is concluded that all forms of PUVA therapy, independently of the route of 8-MOP administration, contribute to a small but dose-dependent increase in nonmelanoma skin cancer risk.
Keywords
Administration, Oral
Administration, Topical
Baths/*adverse effects
DNA Adducts/biosynthesis
Female
Humans
Lymphoma, T-Cell, Cutaneous/drug therapy
Male
Methoxsalen/*administration & dosage/*adverse effects/analogs &
derivatives/pharmacokinetics
Mutagenesis
PUVA Therapy/*adverse effects/*methods
Photosensitizing Agents/administration & dosage/adverse effects
Psoriasis/drug therapy
Skin Diseases/drug therapy
Skin Neoplasms/chemically induced/*epidemiology
Subcellular Fractions/drug effects
Trioxsalen/administration & dosage/adverse effects
Vitiligo/drug therapy
Pubmed
Web of science
Create date
25/01/2008 17:54
Last modification date
20/08/2019 14:37