Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy

Détails

ID Serval
serval:BIB_3FF45182E5CD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy
Périodique
Dermatology
Auteur(s)
Shephard  S. E., Panizzon  R. G.
ISSN
1018-8665 (Print)
Statut éditorial
Publié
Date de publication
1999
Volume
199
Numéro
2
Pages
106-12
Notes
Comparative Study
Journal Article
Résumé
The potential carcinogenic risk of bath PUVA therapy was compared to that of systemic (oral) PUVA. An analysis of the epidemiological data on cancer risk following bath PUVA with trimethylpsoralen does not support the conclusion that bath PUVA per se is less carcinogenic than systemic PUVA with 8-methoxypsoralen (8-MOP). Pharmacokinetic studies indicate that both the concentration of 8-MOP in the target organ for PUVA carcinogenicity (skin) at the relevant time point (time point of UVA irradiation) and the extents of biological effects in the skin are comparable following bathwater or systemic 8-MOP administration. Furthermore, the therapeutic effects of PUVA arise from the same photochemical reaction mechanisms as do the carcinogenic effects. Theoretically, the ratio of (desired) cytotoxic versus (undesired) mutagenic effects could increase with increasing efficiency of the PUVA therapy itself. On the basis of the available evidence, it is concluded that all forms of PUVA therapy, independently of the route of 8-MOP administration, contribute to a small but dose-dependent increase in nonmelanoma skin cancer risk.
Mots-clé
Administration, Oral Administration, Topical Baths/*adverse effects DNA Adducts/biosynthesis Female Humans Lymphoma, T-Cell, Cutaneous/drug therapy Male Methoxsalen/*administration & dosage/*adverse effects/analogs & derivatives/pharmacokinetics Mutagenesis PUVA Therapy/*adverse effects/*methods Photosensitizing Agents/administration & dosage/adverse effects Psoriasis/drug therapy Skin Diseases/drug therapy Skin Neoplasms/chemically induced/*epidemiology Subcellular Fractions/drug effects Trioxsalen/administration & dosage/adverse effects Vitiligo/drug therapy
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 13:37
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