A study of the alkaline proteases secreted by different Aspergillus species

Détails

ID Serval
serval:BIB_3FA7B23EE81C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A study of the alkaline proteases secreted by different Aspergillus species
Périodique
Mycoses
Auteur(s)
Hanzi  M., Shimizu  M., Hearn  V. M., Monod  M.
ISSN
0933-7407 (Print)
Statut éditorial
Publié
Date de publication
12/1993
Volume
36
Numéro
11-12
Pages
351-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov-Dec
Résumé
Strains from several species of Aspergillus were grown in the presence of soluble collagen, and the major secreted proteins present in the culture fluid were examined for proteolytic activity. The possibility of relatedness among the alkaline proteases secreted by Aspergillus was studied by probing extracts from the various species with polyclonal antisera raised to the isolated alkaline proteases of A. fumigatus and A. oryzae. The pathogenic species A. flavus, A. terreus and A. nidulans hydrolyse collagen and were found to secrete an alkaline protease related to that of Aspergillus fumigatus. In contrast, A. niger and non-pathogenic species such A. glaucus, A. versicolor and A. clavatus were unable to degrade collagen in vitro. These findings suggest a possible pathogenic role for the secreted alkaline proteases of Aspergillus species.
Mots-clé
Aspergillus/*enzymology Collagen/pharmacology Endopeptidases/*metabolism Immunoblotting Species Specificity
Pubmed
Web of science
Création de la notice
25/01/2008 17:47
Dernière modification de la notice
03/03/2018 16:25
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