Wirksamkeit und Kosten einer kontinuierlichen Langzeit- behandlung mit Esomeprazol versus einer Anwendung bei Bedarf bei symptomatischen Reflux-Patienten in der Praxis ohne endoskopische Abklarung-die ONE Studie (On-demand Nexium Evaluation). [Long-term treatment of patients with symptomatic gastroesophageal reflux disease comparing costs and efficacy over 6 months of treatment with Nexium On-Demand Treatment or Nexium continuous treatment. An open, randomised multi-center study]

Détails

ID Serval
serval:BIB_3F3D1A55667A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Wirksamkeit und Kosten einer kontinuierlichen Langzeit- behandlung mit Esomeprazol versus einer Anwendung bei Bedarf bei symptomatischen Reflux-Patienten in der Praxis ohne endoskopische Abklarung-die ONE Studie (On-demand Nexium Evaluation). [Long-term treatment of patients with symptomatic gastroesophageal reflux disease comparing costs and efficacy over 6 months of treatment with Nexium On-Demand Treatment or Nexium continuous treatment. An open, randomised multi-center study]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Beglinger  C., Thalmann  C., Szucs  T., Michetti  P.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
03/2006
Volume
95
Numéro
13
Pages
483-7
Notes
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial --- Old month value: Mar 29
Résumé
This open, randomized study (ONE: On-demand Nexium Evaluation) compared the two long-term management options with esomeprazole 20 mg--continuous daily or on-demand treatment--in endoscopically uninvestigated patients seeking primary care for symptoms suggestive of gastroesophageal reflux disease (GERD) who demonstrated complete relief of symptoms after four weeks of initial treatment with esomeprazole 40 mg. In total 1904 patients were randomized. During 26 weeks 913 patients received continuous daily therapy with esomeprazole 20 mg, once daily, while 991 patients were treated with esomeprazole 20 mg on-demand. The continuous therapy offered slightly better relief of the symptom heartburn, however esomeprazole 20 mg taken on-demand was associated with lower direct medical costs. Esomeprazole was generally well tolerated.
Mots-clé
Adolescent Adult Anti-Ulcer Agents/administration & dosage/adverse effects/*economics/*therapeutic use Data Interpretation, Statistical Endoscopy Female Gastroesophageal Reflux/diagnosis/*drug therapy/*economics Humans Male Middle Aged Omeprazole/administration & dosage/adverse effects/*economics/*therapeutic use Patient Satisfaction Patient Selection Time Factors Treatment Outcome
Pubmed
Création de la notice
25/01/2008 17:01
Dernière modification de la notice
20/08/2019 14:36
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