Article: article from journal or magazin.
Direct analysis of valsartan or candesartan in human plasma and urines by on-line solid phase extraction coupled to electrospray tandem mass spectrometry.
Journal of Chromatography. B, Analytical Technologies In the Biomedical and Life Sciences
Publication types: Evaluation Studies ; Journal ArticlePublication Status: ppublish
AT1 receptor blockers are agents for the treatment of hypertension. Rapid and precise assay methods are needed to evaluate possible sub- or overdosage. A direct on-line solid phase extraction coupled to tandem mass spectrometry was developed and validated to determine valsartan (5-2000ng/mL) or candesartan (1-200ng/mL) in human plasma and urines. Both intra- and inter-assay accuracy and precision were in the range 89.2-111% and 0.9-16.9% RSD. Total run time was 4.5min. This on-line clean-up-MS method was found to be robust for the analysis of a high number of samples with unvarying performance.
Benzimidazoles/blood, Benzimidazoles/urine, Humans, Sensitivity and Specificity, Solid Phase Extraction/methods, Tandem Mass Spectrometry/methods, Tetrazoles/blood, Tetrazoles/urine, Valine/analogs & derivatives, Valine/blood
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