Relation of cardiac troponin I measurements at 24 and 48 hours to magnetic resonance-determined infarct size in patients with ST-elevation myocardial infarction.

Détails

ID Serval
serval:BIB_3C6C024EE79B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Relation of cardiac troponin I measurements at 24 and 48 hours to magnetic resonance-determined infarct size in patients with ST-elevation myocardial infarction.
Périodique
American Journal of Cardiology
Auteur(s)
Hallén J., Buser P., Schwitter J., Petzelbauer P., Geudelin B., Fagerland M.W., Jaffe A.S., Atar D.
ISSN
1879-1913 (Electronic)
ISSN-L
0002-9149
Statut éditorial
Publié
Date de publication
2009
Volume
104
Numéro
11
Pages
1472-1477
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Levels of circulating cardiac troponin I (cTnI) or T are correlated to extent of myocardial destruction after an acute myocardial infarction. Few studies analyzing this relation have employed a second-generation cTnI assay or cardiac magnetic resonance (CMR) as the imaging end point. In this post hoc study of the Efficacy of FX06 in the Prevention of Mycoardial Reperfusion Injury (F.I.R.E.) trial, we aimed at determining the correlation between single-point cTnI measurements and CMR-estimated infarct size at 5 to 7 days and 4 months after a first-time ST-elevation myocardial infarction (STEMI) and investigating whether cTnI might provide independent prognostic information regarding infarct size at 4 months even taking into account early infarct size. Two hundred twenty-seven patients with a first-time STEMI were included in F.I.R.E. All patients received primary percutaneous coronary intervention within 6 hours from onset of symptoms. cTnI was measured at 24 and 48 hours after admission. CMR was conducted within 1 week of the index event (5 to 7 days) and at 4 months. Pearson correlations (r) for infarct size and cTnI at 24 hours were r = 0.66 (5 days) and r = 0.63 (4 months) and those for cTnI at 48 hours were r = 0.67 (5 days) and r = 0.65 (4 months). In a multiple regression analysis for predicting infarct size at 4 months (n = 141), cTnI and infarct location retained an independent prognostic role even taking into account early infarct size. In conclusion, a single-point cTnI measurement taken early after a first-time STEMI is a useful marker for infarct size and might also supplement early CMR evaluation in prediction of infarct size at 4 months.
Mots-clé
Aged, Angioplasty, Balloon, Coronary, Austria, Biological Markers/blood, Electrocardiography, Female, Fibrin Fibrinogen Degradation Products/therapeutic use, Heart Conduction System/physiopathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Minnesota, Models, Statistical, Myocardial Infarction/blood, Myocardial Infarction/diagnosis, Myocardial Reperfusion Injury/prevention & control, Norway, Peptide Fragments/therapeutic use, Predictive Value of Tests, Prognosis, Randomized Controlled Trials as Topic, Regression Analysis, Research Design, Risk Factors, Sensitivity and Specificity, Switzerland, Time Factors, Troponin I/blood, Troponin T/blood
Pubmed
Web of science
Création de la notice
04/01/2010 17:31
Dernière modification de la notice
20/08/2019 14:32
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