Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.

Brown, A.E.; Gifford, R.J.; Clewley, J.P.; Kucherer, C.; Masquelier, B.; Porter, K.; Balotta, C.; Back, N.K.; Jorgensen, L.B.; de Mendoza, C.; Bhaskaran, K.; Gill, O.N.; Johnson, A.M.; Pillay, D.; Concerted Action on Seroconversion to, AIDS

doi:10.1086/596049

Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.

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Serval ID

serval:BIB_3B1DACE3A432

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.

Journal

Journal of Infectious Diseases

Author(s)

Brown A.E., Gifford R.J., Clewley J.P., Kucherer C., Masquelier B., Porter K., Balotta C., Back N.K., Jorgensen L.B., de Mendoza C., Bhaskaran K., Gill O.N., Johnson A.M., Pillay D., Concerted Action on Seroconversion to AIDS

Working group(s)

Death in Europe (CASCADE) Collaboration

Contributor(s)

Concerted Action on Seroconversion to AIDS, Del Amo J., Meyer L., Bucher H., Chene G., Pillay D., Prins M., Rosinska M., Sabin C., Touloumi G., Porter K., Lodi S., Walker S., Babiker A., Darbyshire J., Bucher H., de Luca A., Fisher M., Muga R., Kaldor J., Kelleher T., Ramacciotti T., Gelgor L., Cooper D., Smith D., Gill J., Jorgensen LB., Nielsen C., Pedersen C., Lutsar I., Chene G., Dabis F., Thiebaut R., Masquelier B., Costagliola D., Guiguet M., Vanhems P., Meyer L., Boufassa F., Hamouda O., Kucherer C., Touloumi G., Pantazis N., Hatzakis A., Paraskevis D., Karafoulidou A., Rezza G., Dorrucci M., Longo B., Balotta C., Prins M., van Asten L., van der Bij A., Geskus R., Coutinho R., Sannes M., Brubakk O., Eskild A., Bruun JN., Camacho R., Smolskaya T., Muga R., Garcia de Olalla P., Del Amo J., del Romero J., Perez-Hoyos S., Hernandez Aguado I., Bucher H., Rickenbach M., Francioli P., Malyuta R., Brettle R., Delpech V., Lattimore S., Murphy G., Parry J., Gill N., Sabin C., Lee C., Porter K., Johnson A., Phillips A., Babiker A., Darbyshire J., Delpech V., Pillay D., Jaffe H.

ISSN

0022-1899 (Print)

ISSN-L

0022-1899

Publication state

Published

Issued date

02/2009

Peer-reviewed

Oui

Volume

199

Number

Pages

427-431

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

Keywords

Acute Disease, Female, Genes, pol/genetics, Genetic Variation, HIV Infections/epidemiology, HIV Infections/transmission, HIV-1/classification, HIV-1/genetics, Humans, Male, Phylogeny

OAI-PMH

oai:serval.unil.ch:BIB_3B1DACE3A432

DOI

10.1086/596049

Pubmed

19133810

Web of science

000262326600019

Open Access

Yes

Create date

05/03/2009 17:02