Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.

Détails

ID Serval
serval:BIB_39931E96E5C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.
Périodique
American Journal of Human Genetics
Auteur(s)
Bickeböller H., Campion D., Brice A., Amouyel P., Hannequin D., Didierjean O., Penet C., Martin C., Pérez-Tur J., Michon A., Dubois B., Ledoze F., Thomas-Anterion C., Pasquier F., Puel M., Demonet J.F., Moreaud O., Babron M.C., Meulien D., Guez D., Chartier-Harlin M.C., Frebourg T., Agid Y., Martinez M., Clerget-Darpoux F.
ISSN
0002-9297 (Print)
ISSN-L
0002-9297
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
60
Numéro
2
Pages
439-446
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the APOE epsilon2 allele (OR[epsilon2] = 0.5 with 95% CI = 0.3-0.98; P = .012) were retrieved. An effect of the epsilon4 allele dosage on susceptibility was confirmed (OR[epsilon4/epsilon4] vs. the epsilon3/epsilon3 genotype = 11.2 [95% CI = 4.0-31.6]; OR[epsilon3/epsilon4] vs. the epsilon3/epsilon3 genotype = 2.2 [95% CI = 1.5-3.5]). The frequency of the epsilon4 allele was lower in male cases than in female cases, but, since a similar difference was found in controls, this does not lead to a difference in OR between sex. ORs for the epsilon4 allele versus the epsilon3 allele, OR(epsilon4), were not equal in all age classes: OR(epsilon4) in the extreme groups with onset at < 60 years or > 79 years were significantly lower than those from the age groups 60-79 years. In epsilon3/epsilon4 individuals, sex-specific lifetime risk estimates by age 85 years (i.e., sex-specific penetrances by age 85 years) were 0.14 (95% CI 0.04-0.30) for men and 0.17 (95% CI 0.09-0.28) for women.
Mots-clé
Age of Onset, Aged, Aged, 80 and over, Aging, Alzheimer Disease/genetics, Apolipoprotein E2, Apolipoprotein E3, Apolipoprotein E4, Apolipoproteins E/genetics, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Heterozygote, Homozygote, Humans, Male, Middle Aged, Odds Ratio, Risk Factors, Sex Characteristics
Pubmed
Web of science
Création de la notice
24/03/2013 17:36
Dernière modification de la notice
20/08/2019 14:29
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