Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance.

Details

Serval ID
serval:BIB_38A49E91C6FB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance.
Journal
International Journal of Tuberculosis and Lung Disease
Author(s)
Clin B., Luc A., Morlais F., Paris C., Ameille J., Brochard P., De Girolamo J., Gislard A., Laurent F., Letourneux M., Schorle E., Launoy G., Pairon J.C.
Working group(s)
National Network of Asbestos Post-Exposure Survey (APEXS)
Contributor(s)
Badachi Y., Baron J., Beigelman C., Chamming's S., Conso F., Ferretti G., Jankowski A., Latrabe V., Montaudon M., Stoufflet A.
ISSN
1815-7920 (Electronic)
ISSN-L
1027-3719
Publication state
Published
Issued date
2011
Volume
15
Number
12
Pages
1707-1714
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVE: To analyse the relationship between pulmonary nodules detected by radiologists using computed tomography and cumulative exposure to asbestos or asbestos-related pleuro-pulmonary diseases in 5662 asbestos-exposed subjects, and the relationship between pulmonary nodules and thoracic cancer, to determine whether a specific surveillance strategy based on cumulative asbestos exposure should be adopted.
DESIGN: Standardised incidence and mortality ratios (SIR) for lung cancer and pleural mesothelioma were calculated in patients with and without mention of pulmonary nodules and compared using comparative morbidity figures.
RESULTS: A significant excess incidence of primary lung cancer and pleural mesothelioma was observed among subjects presenting with pulmonary nodule(s) (SIR respectively 1.95, 95%CI 1.22-2.95, and 11.88, 95%CI 3.20-30.41). However, there was no significant relationship between pulmonary nodules mentioned by radiologists and cumulative asbestos exposure or between pulmonary nodules and the presence of asbestos-related benign diseases.
CONCLUSIONS: This study confirms the expected excess prevalence of lung cancer in subjects presenting with pulmonary nodules according to the radiologist's report, and shows the absence of relationship between the presence of nodules and level of cumulative asbestos exposure. Our study therefore offers no argument in favour of specific surveillance modalities based on estimated cumulative asbestos exposure.
Keywords
Aged, Asbestos/toxicity, Carcinogens/toxicity, Female, Humans, Incidence, Lung Neoplasms/chemically induced, Lung Neoplasms/pathology, Male, Mass Screening/methods, Mesothelioma/chemically induced, Mesothelioma/pathology, Middle Aged, Multiple Pulmonary Nodules/pathology, Multiple Pulmonary Nodules/radiography, Occupational Exposure/adverse effects, Pleural Neoplasms/chemically induced, Pleural Neoplasms/pathology, Population Surveillance, Prevalence, Solitary Pulmonary Nodule/pathology, Solitary Pulmonary Nodule/radiography, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Create date
07/05/2012 14:03
Last modification date
20/08/2019 13:28
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