Metformine: nouvelles données pour une ancienne molecule [Metformin: new data for an old molecule].

Détails

ID Serval
serval:BIB_3743779B7147
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Metformine: nouvelles données pour une ancienne molecule [Metformin: new data for an old molecule].
Périodique
Revue Médicale Suisse
Auteur(s)
Sanduloviciu M., Jornayvaz F.R.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2015
Volume
11
Numéro
477
Pages
1222-1226
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Résumé
Metformin is the first-line oral agent for the treatment of type 2 diabetes according to the guidelines. Metformin decreases hepatic glucose production, does not induce weight gain and does not increase the risk of hypoglycemia. However, decades after its introduction, its mode of action has been only recently highlighted. The side effects of metformin are well known and consist primarily of digestive problems. Although rare, the dreaded complication is lactic acidosis, which can develop in patients with severe renal insufficiency or in conditions of low perfusion. The purpose of this article is to review the indications, risks and benefits of this drug, but also to discuss new evidence related to its mechanism of action and the conditions that increase the risk of lactic acidosis.
Mots-clé
Blood Glucose/drug effects, Body Weight/drug effects, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/prevention & control, Diabetes Mellitus, Type 2/drug therapy, Humans, Hypoglycemic Agents/therapeutic use, Incidence, Metformin/therapeutic use, Neoplasms/epidemiology, Neoplasms/prevention & control, Obesity/drug therapy
Pubmed
Création de la notice
10/09/2015 12:51
Dernière modification de la notice
03/03/2018 16:04
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