Lack of prognostic usefulness of hepatic venous pressures and hemodynamic values in a select group of patients with severe alcoholic cirrhosis.
Details
Serval ID
serval:BIB_3533AF212757
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of prognostic usefulness of hepatic venous pressures and hemodynamic values in a select group of patients with severe alcoholic cirrhosis.
Journal
American Journal of Gastroenterology
ISSN
0002-9270 (Print)
ISSN-L
0002-9270
Publication state
Published
Issued date
2002
Volume
97
Number
5
Pages
1187-1190
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
OBJECTIVE: Prognostic assessment of patients with alcoholic cirrhosis is still controversial. A prospective study was performed to evaluate hemodynamic values as prognostic factors of death in a group of patients with severe alcoholic cirrhosis.
METHODS: From January, 1991 to February, 1993, a total of 87 admitted patients were prospectively studied. Measurements of the hepatic venous pressure gradient and cardiac output were performed in all patients. The mean follow-up was 35 months (range 1-76 months).
RESULTS: During this period, 56 patients (63% at 5 yr) died. The hepatic venous pressure gradient and cardiac output were not significantly different between the two groups. Using univariate analysis, only age and bilirubin concentration were different between those patients who lived and those who died. Cox regression analysis showed that age, encephalopathy, bilirubin concentration. prothrombin time, and Child-Pugh score were the only prognostic factors.
CONCLUSION: Measurement of the hepatic venous pressure gradient is not helpful in the prognostic assessment in a select group of patients with severe alcoholic cirrhosis.
METHODS: From January, 1991 to February, 1993, a total of 87 admitted patients were prospectively studied. Measurements of the hepatic venous pressure gradient and cardiac output were performed in all patients. The mean follow-up was 35 months (range 1-76 months).
RESULTS: During this period, 56 patients (63% at 5 yr) died. The hepatic venous pressure gradient and cardiac output were not significantly different between the two groups. Using univariate analysis, only age and bilirubin concentration were different between those patients who lived and those who died. Cox regression analysis showed that age, encephalopathy, bilirubin concentration. prothrombin time, and Child-Pugh score were the only prognostic factors.
CONCLUSION: Measurement of the hepatic venous pressure gradient is not helpful in the prognostic assessment in a select group of patients with severe alcoholic cirrhosis.
Keywords
Bilirubin/blood, Cardiac Output, Female, Hepatic Veins, Humans, Liver Cirrhosis, Alcoholic/mortality, Liver Cirrhosis, Alcoholic/physiopathology, Male, Middle Aged, Osmolar Concentration, Prognosis, Prospective Studies, Regression Analysis, Severity of Illness Index, Venous Pressure
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Web of science
Create date
06/12/2013 11:28
Last modification date
20/08/2019 14:22
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