Roles of exosomes in cardioprotection.

Détails

ID Serval
serval:BIB_34B794B22FFA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Roles of exosomes in cardioprotection.
Périodique
European heart journal
Auteur(s)
Barile L., Moccetti T., Marbán E., Vassalli G.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Statut éditorial
Publié
Date de publication
07/05/2017
Peer-reviewed
Oui
Volume
38
Numéro
18
Pages
1372-1379
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Exosomes are extracellular vesicles of endosomal origin which have emerged as key mediators of intercellular communication. All major cardiac cell types-including cardiomyocytes, endothelial cells, and fibroblasts-release exosomes that modulate cellular functions. Exosomes released from human cardiac progenitor cells (CPCs) are cardioprotective and improve cardiac function after myocardial infarction to an extent comparable with that achieved by their parent cells. Cardiac progenitor cell-derived exosomes are enriched in cardioprotective microRNAs, particularly miR-146a-3p. Circulating exosomes mediate remote ischaemic preconditioning. Moreover, they currently are being investigated as diagnostic markers. The discovery that cell-derived extracellular signalling organelles mediate the paracrine effects of stem cells suggests that cell-free strategies could supplant cell transplantation. This review discusses emerging roles of exosomes in cardiovascular physiology, with a focus on cardioprotective activities of CPC-derived exosomes.

Mots-clé
Biomarkers/metabolism, Cardiovascular Diseases/physiopathology, Endothelial Cells/secretion, Exosomes/physiology, Exosomes/secretion, Humans, Ischemic Preconditioning, Myocardial/methods, Myoblasts, Cardiac/secretion, Myocytes, Cardiac/physiology, Myocytes, Cardiac/secretion, Stem Cells/secretion, Cardioprotection, Exosomes, Progenitor cells
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/12/2016 15:14
Dernière modification de la notice
20/08/2019 14:21
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