Evaluation of ablation patterns using a biophysical model of atrial fibrillation

Details

Serval ID
serval:BIB_34B7325D5071
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of ablation patterns using a biophysical model of atrial fibrillation
Journal
Annals of Biomedical Engineering
Author(s)
Dang  L., Virag  N., Ihara  Z., Jacquemet  V., Vesin  J. M., Schlaepfer  J., Ruchat  P., Kappenberger  L.
ISSN
0090-6964 (Print)
Publication state
Published
Issued date
04/2005
Volume
33
Number
4
Pages
465-74
Notes
Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Validation Studies --- Old month value: Apr
Abstract
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Surgical/Radiofrequency (RF) ablation is a therapeutic procedure that consists of creating lines of conduction block to interrupt AF. The present study evaluated 13 different ablation patterns by means of a biophysical model of the human atria. In this model, ablation lines were abruptly applied transmurally during simulated sustained AF, and success rate, time to AF termination and average beat-to-beat interval were documented. The gold standard Cox's Maze III procedure was taken as reference. The effectiveness of twelve less invasive patterns was compared to it. In some of these incomplete lines (entailing a gap) were simulated. Finally, the computer simulations were compared to clinical data. The results show that the model reproduces observations made in vivo: (1) the Maze III is the most efficient ablation procedure; (2) less invasive patterns should include lines in both right and left atrium; (3) incomplete ablation lines between the pulmonary veins and the mitral valve annulus lead to uncommon flutter; (4) computer simulations of incomplete lines are consistent with clinical results of non-transumural RF ablation. Biophysical modeling may therefore be considered as a useful tool for understanding the mechanisms underlying AF therapies.
Keywords
Atrial Fibrillation/diagnosis/*physiopathology/*surgery Catheter Ablation/*methods Computer Simulation Heart Conduction System/*physiopathology/*surgery Humans *Models, Cardiovascular Models, Neurological Prognosis Surgery, Computer-Assisted/*methods Treatment Outcome
Pubmed
Web of science
Create date
28/01/2008 10:09
Last modification date
20/08/2019 13:21
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