Effects of zolpidem on the architecture and cyclical structure of sleep in poor sleepers.

Details

Serval ID
serval:BIB_33C6F8CE9A47
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of zolpidem on the architecture and cyclical structure of sleep in poor sleepers.
Journal
Drugs under Experimental and Clinical Research
Author(s)
Besset A., Tafti M., Villemin E., Borderies P., Billiard M.
ISSN
0378-6501[print], 0378-6501[linking]
Publication state
Published
Issued date
1995
Volume
21
Number
4
Pages
161-169
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
Effects of zolpidem, a short acting non benzodiazepine hypnotic, have been studied in eight female poor sleepers, aged 25 to 54 years, documented during two consecutive adaptation nights. Subjects were recorded according to a 22 day single blind study. Placebo was given orally at bedtime on nights 2-4, zolpidem on nights 5-20 and finally placebo on nights 21-22. Polygraphic recordings (conventional analysis) were performed on nights 1-6; 12, 13; 19-22. Parameters of sleep continuity, sleep architecture and cyclical structure of sleep were studied. Zolpidem 10 mg showed a hypnotic effect on poor sleepers. It reduced sleep latency, increased total sleep time and decreased the number of awakenings during all recorded nights. During the first post-drug night a rebound insomnia was observed in two subjects only. Zolpidem did not increase specifically stage 2 to the detriment of stages 3 and 4 but it restored them during the first nights of administration. Study of the rapid eye movements-non rapid eye movements (REM-NREM) sleep cycles structure showed that the increase of stages 3 and 4 occurred only during the first part of the night. Finally, zolpidem had no effect on REM sleep temporal distribution.
Keywords
Adult, Female, Humans, Hypnotics and Sedatives/therapeutic use, Middle Aged, Pyridines/therapeutic use, Sleep Disorders/drug therapy, Sleep Stages/drug effects, Sleep, REM/drug effects
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 13:20
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