Direct transport of progesterone from vagina to uterus

Details

Serval ID
serval:BIB_33869E97D034
Type
Article: article from journal or magazin.
Collection
Publications
Title
Direct transport of progesterone from vagina to uterus
Journal
Obstetrics and Gynecology
Author(s)
Cicinelli  E., de Ziegler  D., Bulletti  C., Matteo  M. G., Schonauer  L. M., Galantino  P.
ISSN
0029-7844
Publication state
Published
Issued date
03/2000
Peer-reviewed
Oui
Volume
95
Number
3
Pages
403-6
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Mar
Abstract
OBJECTIVE: To compare progesterone concentrations in serum and endometrial tissue from hysterectomy specimens after vaginal or intramuscular (IM) administration of progesterone gel. METHODS: This was a randomized open study of 14 post-menopausal women undergoing transabdominal hysterectomies. Participants received either vaginal progesterone gel, 90 mg, or IM progesterone, 50 mg, at 8:00 AM and 8:00 PM on the day before surgery and at 6:00 AM on the day of surgery. Venous blood samples for progesterone measurement were collected at 8:00 AM on the day before surgery (baseline) and during surgery. After removal of the uterus, the endometrium was sampled from the anterior and posterior walls. Results were expressed as ratios of endometrial to serum progesterone concentrations x 100. RESULTS: Ratios of endometrial to serum progesterone concentrations were markedly higher in women who received vaginal progesterone (14.1 median, 8.5-59.4 range; 95% confidence interval [CI] 9.89, 38.79) compared with IM injections (1.2 median, 0.5-13.1 range; 95% CI -0.48, 7.39) (P < .005). CONCLUSION: Ratios of endometrial to serum progesterone concentrations were higher after vaginal administration of progesterone than after IM injections. Our findings in endometrial tissue specimens from hysterectomies excluded the possibility of contamination by progesterone that remained in the vagina.
Keywords
Administration, Intravaginal Biological Transport Female Humans Injections, Intramuscular Middle Aged Progesterone/administration & dosage/blood/*pharmacokinetics Uterus/*metabolism Vagina/*metabolism
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 13:19
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