Article: article from journal or magazin.
Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.
Assay and Drug Development Technologies
Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis; others occur spontaneously in human diseases. The analysis of constitutively active GPCR mutants has attracted a large interest in the past decade, providing an important contribution to our understanding of the molecular mechanisms underlying receptor function and drug action.
Drug Therapy/trends, Forecasting, Mutagenesis, Site-Directed, Mutation, Receptors, G-Protein-Coupled/drug effects, Receptors, G-Protein-Coupled/genetics
Web of science
Last modification date