Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.

Détails

ID Serval
serval:BIB_31FA9DF0D1C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.
Périodique
Pharmacology, Biochemistry, and Behavior
Auteur(s)
De Blasi A., Lipartiti M., Algeri S., Sacchetti G., Costantini C., Fratelli M., Cotecchia S.
ISSN
0091-3057 (Print)
ISSN-L
0091-3057
Statut éditorial
Publié
Date de publication
1986
Volume
24
Numéro
4
Pages
991-998
Langue
anglais
Résumé
The effects of different times of immobilization stress on intact lymphocyte beta-adrenoceptors and plasma corticosterone were compared in 3-month and 24-month-old rats. In young animals after 30 min restraint 3H-dihydroalprenolol specific binding was significantly reduced (61% of control value) and plasma corticosterone significantly raised (186% of control). The effect on beta-adrenoceptors was due changes in receptor number (Bmax) without any effect on affinity (KD). In aged rats both effects were only seen after 180 min restraint and were less pronounced. Isoproterenol treatment in vitro reduced beta-adrenoceptors on lymphocytes. This effect was less pronounced in lymphocytes from aged rats. Corticosterone in vitro increased 3H-dihydroalprenolol specific binding. We therefore suggest that the decrease of beta-adrenoceptors reflects an adaptive response to the stress-induced catecholamine release and that corticosterone could play a role in reversing this effect. This adaptive response to stress seems to be impaired in aged animals.
Mots-clé
Age Factors, Animals, Corticosterone/blood, Dihydroalprenolol/metabolism, Isoproterenol/diagnostic use, Lymphocytes/physiology, Male, Propanolamines/metabolism, Rats, Rats, Inbred Strains, Receptors, Adrenergic, beta/physiology, Restraint, Physical, Stress, Physiological/physiopathology
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 13:17
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