Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.

Details

Serval ID
serval:BIB_31FA9DF0D1C2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.
Journal
Pharmacology, Biochemistry, and Behavior
Author(s)
De Blasi A., Lipartiti M., Algeri S., Sacchetti G., Costantini C., Fratelli M., Cotecchia S.
ISSN
0091-3057 (Print)
ISSN-L
0091-3057
Publication state
Published
Issued date
1986
Volume
24
Number
4
Pages
991-998
Language
english
Abstract
The effects of different times of immobilization stress on intact lymphocyte beta-adrenoceptors and plasma corticosterone were compared in 3-month and 24-month-old rats. In young animals after 30 min restraint 3H-dihydroalprenolol specific binding was significantly reduced (61% of control value) and plasma corticosterone significantly raised (186% of control). The effect on beta-adrenoceptors was due changes in receptor number (Bmax) without any effect on affinity (KD). In aged rats both effects were only seen after 180 min restraint and were less pronounced. Isoproterenol treatment in vitro reduced beta-adrenoceptors on lymphocytes. This effect was less pronounced in lymphocytes from aged rats. Corticosterone in vitro increased 3H-dihydroalprenolol specific binding. We therefore suggest that the decrease of beta-adrenoceptors reflects an adaptive response to the stress-induced catecholamine release and that corticosterone could play a role in reversing this effect. This adaptive response to stress seems to be impaired in aged animals.
Keywords
Age Factors, Animals, Corticosterone/blood, Dihydroalprenolol/metabolism, Isoproterenol/diagnostic use, Lymphocytes/physiology, Male, Propanolamines/metabolism, Rats, Rats, Inbred Strains, Receptors, Adrenergic, beta/physiology, Restraint, Physical, Stress, Physiological/physiopathology
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 13:17
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