Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor
Details
Serval ID
serval:BIB_31E32ADDCA68
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor
Journal
Neuroscience and Biobehavioral Reviews
ISSN
0149-7634 (Print)
Publication state
Published
Issued date
02/2005
Volume
29
Number
1
Pages
113-23
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Neuropeptide Y (NPY) is primarily synthesised and released by neurones, it is co-localised with noradrenaline and is involved in the regulation of cardiovascular function. In a mouse model lacking NPY Y1 receptor (KO), the ability of NPY to potentiate noradrenaline-induced vasoconstriction is abolished during stress but normal in baseline conditions, locomotor activity and metabolic rate are lowered, blood insulin levels and glucose storage activity are increased. The present study was aimed at further characterising NPY Y1 mutants, with special emphasis on: behavioural responses to novelty seeking and open-field with objects tests, heart rate responsiveness during acute social defeat, alpha2-adrenoceptor (alpha2-ARs) function in brain areas involved in cardiovascular regulation, and cardiac structure. As compared to wild-type controls (n=9), NPY Y1 KOs (n=9) showed: reduced somatomotor activation during non-social challenges, lower heart rate in baseline conditions, larger heart rate responsiveness during social defeat, increased number of alpha2-ARs in the dorsal motor nucleus of the vagus (nX) and the locus coeruleus (LC), moderately larger volume fraction of myocardial fibrosis. The remarkable increment of alpha2-adrenoceptor density in the nX and LC allows to view KO mice behavioural and anatomo-physiological peripheral characteristics as 'adaptations' to central adrenergic rearrangement due to NPY Y1 receptor deletion.
Keywords
Adaptation, Physiological/*physiology
Analysis of Variance
Animals
Autoradiography/methods
Behavior, Animal/*physiology
Cardia/pathology
*Cardiovascular System
Choice Behavior/physiology
Clonidine/pharmacology
Electrocardiography/methods
Exploratory Behavior/physiology
Heart Rate/physiology
Locus Coeruleus/drug effects
Male
Mice
Mice, Knockout
Motor Activity/physiology
Psychomotor Performance/physiology
Receptors, Adrenergic, alpha-2/agonists/metabolism
Receptors, Neuropeptide Y/*deficiency/genetics
Stress, Psychological/*physiopathology
Telemetry/methods
Time Factors
Tritium/pharmacology
Pubmed
Web of science
Create date
25/01/2008 9:45
Last modification date
20/08/2019 14:17