Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy

Details

Serval ID
serval:BIB_300AAC488520
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy
Journal
Neuroreport
Author(s)
Tseng  J. L., Bruhn  S. L., Zurn  A. D., Aebischer  P.
ISSN
0959-4965 (Print)
Publication state
Published
Issued date
06/1998
Volume
9
Number
8
Pages
1817-22
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Abstract
To determine whether neurturin (NTN), a recently identified homologue of glial cell line-derived neurotrophic factor (GDNF), is able to preserve tyrosine hydroxylase immunoreactivity (TH-IR) in a rat model of Parkinson's disease, polymer encapsulated cells genetically engineered to release NTN were implanted near the substantia nigra 1 week before a unilateral medial forebrain bundle axotomy. Animals were allowed to survive for 1 week post-axotomy. Upon sacrifice, animals that received a NTN capsule had a significantly higher percentage of TH-IR (lesioned side vs non-lesioned side) than animals that had received a capsule containing non-transfected parent cells. However, in contrast to GDNF, no reduction of turning was observed upon amphetamine rotation with NTN. Nevertheless, these results suggest that NTN might have a therapeutic value for the treatment of Parkinson's disease.
Keywords
Analysis of Variance Animals Axotomy Cell Line Cricetinae Dopamine/*physiology Female Immunohistochemistry Nerve Growth Factors/*pharmacology Neurons/*drug effects Neuroprotective Agents/*pharmacology Neurturin Prosencephalon/*drug effects/surgery Rats Rats, Wistar Tyrosine 3-Monooxygenase/analysis
Pubmed
Web of science
Create date
28/01/2008 8:44
Last modification date
20/08/2019 13:14
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