Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy
Details
Serval ID
serval:BIB_300AAC488520
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy
Journal
Neuroreport
ISSN
0959-4965 (Print)
Publication state
Published
Issued date
06/1998
Volume
9
Number
8
Pages
1817-22
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Abstract
To determine whether neurturin (NTN), a recently identified homologue of glial cell line-derived neurotrophic factor (GDNF), is able to preserve tyrosine hydroxylase immunoreactivity (TH-IR) in a rat model of Parkinson's disease, polymer encapsulated cells genetically engineered to release NTN were implanted near the substantia nigra 1 week before a unilateral medial forebrain bundle axotomy. Animals were allowed to survive for 1 week post-axotomy. Upon sacrifice, animals that received a NTN capsule had a significantly higher percentage of TH-IR (lesioned side vs non-lesioned side) than animals that had received a capsule containing non-transfected parent cells. However, in contrast to GDNF, no reduction of turning was observed upon amphetamine rotation with NTN. Nevertheless, these results suggest that NTN might have a therapeutic value for the treatment of Parkinson's disease.
Keywords
Analysis of Variance
Animals
Axotomy
Cell Line
Cricetinae
Dopamine/*physiology
Female
Immunohistochemistry
Nerve Growth Factors/*pharmacology
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Neurturin
Prosencephalon/*drug effects/surgery
Rats
Rats, Wistar
Tyrosine 3-Monooxygenase/analysis
Pubmed
Web of science
Create date
28/01/2008 8:44
Last modification date
20/08/2019 13:14