Greffes intracérébrales dans la maladie de Parkinson. Expérience actuelle et perspectives [Intracerebral grafts in Parkinson disease. Current experiences and perspectives].

Details

Serval ID
serval:BIB_2E59019E0539
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Greffes intracérébrales dans la maladie de Parkinson. Expérience actuelle et perspectives [Intracerebral grafts in Parkinson disease. Current experiences and perspectives].
Journal
Bulletin et Mémoires de l'académie Royale de Médecine de Belgique
Author(s)
Levivier M.
ISSN
0377-8231 (Print)
ISSN-L
0377-8231
Publication state
Published
Issued date
1999
Volume
154
Number
1
Pages
99-109
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Six patients with advanced Parkinson's disease have been grafted with human fetal neuronal cells. This clinical work is based on the technique originally described by the groups of Lund, Sweden and Créteil, France, with which we closely collaborate. A first group of 3 patients was grafted between 1995 and 1996, with neuronal tissue obtained from same-day abortions. We have observed bilateral improvement of motor functions after unilateral transplantation into the putamen. One patient had a second graft, into the heterolateral putamen, one year after the first one. Another group of 3 patients was operated between 1997 and 1998, and received grafts of hibernated tissue, in order to facilitate the technical organization of the transplantation procedure. Altogether, these clinical results are encouraging, but the technical and ethical limitations related with the use of human fetal tissue prompted us to develop alternative solutions, such as the use of xenografts and the transplantation of genetically modified cells.
Keywords
Brain Tissue Transplantation/methods, Brain Tissue Transplantation/trends, Ethics, Medical, Fetal Tissue Transplantation/methods, Fetal Tissue Transplantation/trends, Genetic Engineering, Humans, Neurons/transplantation, Parkinson Disease/surgery, Putamen/surgery, Transplantation, Heterologous
Pubmed
Create date
20/01/2008 17:35
Last modification date
20/08/2019 13:12
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