Magnetic resonance stress tagging in ischemic heart disease.

Details

Serval ID
serval:BIB_2E187E4572AB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Magnetic resonance stress tagging in ischemic heart disease.
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Paetsch I., Föll D., Kaluza A., Luechinger R., Stuber M., Bornstedt A., Wahl A., Fleck E., Nagel E.
ISSN
0363-6135[print], 0363-6135[linking]
Publication state
Published
Issued date
2005
Volume
288
Number
6
Pages
H2708-H2714
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
High-dose dobutamine magnetic resonance stress testing has been shown to be superior to dobutamine stress echocardiography for diagnosis of coronary artery disease (CAD). We determined the feasibility of quantitative myocardial tagging during low- and high-dose dobutamine stress and tested the ability of global systolic and diastolic quantitative parameters to identify patients with significant CAD. Twenty-five patients suspected of having significant CAD were examined with a standard high-dose dobutamine/atropine stress magnetic resonance protocol (1.5-T scanner, Philips). All patients underwent invasive coronary angiography as the standard of reference for the presence (n = 13) or absence (n = 12) of significant CAD. During low-dose dobutamine stress, systolic (circumferential shortening, systolic rotation, and systolic rotation velocity) and diastolic (velocity of circumferential lengthening and diastolic rotation velocity) parameters changed significantly in patients without CAD (all P < 0.05 vs. rest) but not in patients with CAD. Identification of patients without and with CAD during low-dose stress was possible using the diastolic parameter of "time to peak untwist." At high-dose stress, none of the global systolic or diastolic parameters showed the potential to identify the presence of significant CAD. With myocardial tagging, a quantitative analysis of systolic and diastolic function was feasible during low- and high-dose dobutamine stress. In our study, the diastolic parameter of time to peak untwist as assessed during low-dose dobutamine stress was the most promising global parameter for identification of patients with significant CAD. Thus quantitative myocardial tagging may become a tool that reduces the need for high-dose dobutamine stress.
Keywords
Adrenergic beta-Agonists/diagnostic use, Aged, Coronary Disease/physiopathology, Coronary Restenosis/physiopathology, Diastole, Dobutamine/diagnostic use, Exercise Test/methods, Female, Heart/physiopathology, Heart Function Tests, Heart Rate, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myocardial Ischemia/physiopathology, Systole
Pubmed
Web of science
Create date
02/03/2010 16:04
Last modification date
20/08/2019 13:12
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