Assessment of early left ventricular remodeling in orthotopic heart transplant recipients with cine magnetic resonance imaging: potential mechanisms.

Détails

ID Serval
serval:BIB_2C42CB55F6BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessment of early left ventricular remodeling in orthotopic heart transplant recipients with cine magnetic resonance imaging: potential mechanisms.
Périodique
Journal of Heart and Lung Transplantation
Auteur(s)
Globits S., De Marco T., Schwitter J., Sakuma H., O'Sullivan M., Rifkin C., Keith F., Chatterjee K., Parmley W.W., Higgins C.B.
ISSN
1053-2498 (Print)
ISSN-L
1053-2498
Statut éditorial
Publié
Date de publication
1997
Volume
16
Numéro
5
Pages
504-510
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
We performed short axis cine magnetic resonance imaging studies in 11 patients 2 months after they underwent orthotopic heart transplantation (OHT), and in 10 control subjects, to measure left ventricular (LV) volumes, mass, and end-systolic wall stress to assess ventricular remodeling after OHT. Although there were no significant differences in ventricular volumes and ejection fractions between heart transplant recipients and control subjects, heart transplant recipients had significantly higher LV mass (198 +/- 61 vs 132 +/- 27 gm, p = 0.001). As a consequence of myocardial hypertrophy, end-systolic wall stress was significantly reduced in heart transplant recipients compared with control subjects (34 +/- 16 vs 57 +/- 10 kdyne/cm2, p = 0.001). Moreover, heart transplant recipients had significantly reduced end-systolic wall stress/volume ratio when compared with control subjects (0.89 +/- 0.3 vs 1.26 +/- 0.3 kdyne/cm2/ml, p < 0.01), indicating an already reduced LV contractility 2 months after heart transplantation. Univariate regression analysis revealed a significant correlation between LV mass and averaged cyclosporine levels, but no correlation between LV mass and blood pressure, cold ischemic time, acute rejection, age, body mass, blood pressure, plasma catecholamine levels, or plasma renin activity. Magnetic resonance imaging demonstrates early LV remodeling after OHT with reduced myocardial contractility. Cyclosporine may be contributing to these changes.
Mots-clé
Adult, Aged, Case-Control Studies, Cyclosporins/adverse effects, Female, Heart Transplantation/adverse effects, Humans, Hypertrophy, Left Ventricular/diagnosis, Hypertrophy, Left Ventricular/etiology, Immunosuppressive Agents/adverse effects, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myocardial Contraction, Regression Analysis, Stroke Volume, Time Factors
Pubmed
Web of science
Création de la notice
07/09/2011 19:28
Dernière modification de la notice
20/08/2019 14:11
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