Movement Preparation and Bilateral Modulation of Beta Activity in Aging and Parkinson?s Disease

Details

Serval ID
serval:BIB_2C067AF1E048
Type
Article: article from journal or magazin.
Collection
Publications
Title
Movement Preparation and Bilateral Modulation of Beta Activity in Aging and Parkinson?s Disease
Journal
PLoS ONE
Author(s)
Meziane Hadj Boumediene, Moisello Clara, Perfetti Bernardo, Kvint Svetlana, Isaias Ioannis Ugo, Quartarone Angelo, Di Rocco Alessandro, Ghilardi Maria Felice
Publication state
Published
Issued date
01/2015
Volume
10
Number
1
Pages
1-14
Language
english
Notes
10.1371/journal.pone.0114817
Abstract
In previous studies of young subjects performing a reaction-time reaching task, we found that faster reaction times are associated with increased suppression of beta power over primary sensorimotor areas just before target presentation. Here we ascertain whether such beta decrease similarly occurs in normally aging subjects and also in patients with Parkinson?s disease (PD), where deficits in movement execution and abnormalities of beta power are usually present. We found that in both groups, beta power decreased during the motor task in the electrodes over the two primary sensorimotor areas. However, before target presentation, beta decreases in PD were significantly smaller over the right than over the left areas, while they were symmetrical in controls. In both groups, functional connectivity between the two regions, measured with imaginary coherence, increased before the target appearance; however, in PD, it decreased immediately after, while in controls, it remained elevated throughout motor planning. As in previous studies with young subjects, the degree of beta power before target appearance correlated with reaction time. The values of coherence during motor planning, instead, correlated with movement time, peak velocity and acceleration. We conclude that planning of prompt and fast movements partially depends on coordinated beta activity of both sensorimotor areas, already at the time of target presentation. The delayed onset of beta decreases over the right region observed in PD is possibly related to a decreased functional connectivity between the two areas, and this might account for deficits in force programming, movement duration and velocity modulation
Open Access
Yes
Create date
31/03/2016 15:00
Last modification date
21/01/2020 14:59
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