Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.

Détails

ID Serval
serval:BIB_2BEDD47445C8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
Périodique
Seminars in immunology
Auteur(s)
Pot C., Apetoh L., Awasthi A., Kuchroo V.K.
ISSN
1096-3618 (Electronic)
ISSN-L
1044-5323
Statut éditorial
Publié
Date de publication
12/2011
Peer-reviewed
Oui
Volume
23
Numéro
6
Pages
438-445
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
Mots-clé
Animals, Autoimmune Diseases/immunology, Humans, Interleukin-10/biosynthesis, Interleukin-10/immunology, Interleukins/immunology, T-Lymphocytes, Regulatory/immunology, Th17 Cells/immunology
Pubmed
Web of science
Création de la notice
21/08/2018 17:06
Dernière modification de la notice
28/08/2018 6:26
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