Intracellular pattern-recognition receptors

Details

Serval ID
serval:BIB_2BE758463B35
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Intracellular pattern-recognition receptors
Journal
Advanced Drug Delivery Reviews
Author(s)
Dostert C., Meylan E., Tschopp J.
ISSN
0169-409X
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
60
Number
7
Pages
830-840
Language
english
Abstract
The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail. More recently, cytoplasmic sensors were identified, which are capable of detecting not only microbial, but also self molecules. Importantly, while such receptors trigger crucial host responses to microbial insult, over-activity of some of them has been linked to autoinflammatory disorders, hence demonstrating the importance of tightly regulating their actions over time and space. Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm
Keywords
Animals , Antiviral Agents , Biochemistry , biosynthesis , Cytoplasm , Dna , Dna,Viral , genetics , Humans , Immunity , Interferon Type I , Nod Signaling Adaptor Proteins , pharmacology , physiology , Proteins , Receptors,Pattern Recognition , Rna , Rna,Viral , Switzerland , therapeutic use
Pubmed
Web of science
Create date
29/01/2009 22:13
Last modification date
20/08/2019 13:11
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