Intracellular pattern-recognition receptors

Détails

ID Serval
serval:BIB_2BE758463B35
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Intracellular pattern-recognition receptors
Périodique
Advanced Drug Delivery Reviews
Auteur(s)
Dostert C., Meylan E., Tschopp J.
ISSN
0169-409X
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
60
Numéro
7
Pages
830-840
Langue
anglais
Résumé
The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail. More recently, cytoplasmic sensors were identified, which are capable of detecting not only microbial, but also self molecules. Importantly, while such receptors trigger crucial host responses to microbial insult, over-activity of some of them has been linked to autoinflammatory disorders, hence demonstrating the importance of tightly regulating their actions over time and space. Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm
Mots-clé
Animals , Antiviral Agents , Biochemistry , biosynthesis , Cytoplasm , Dna , Dna,Viral , genetics , Humans , Immunity , Interferon Type I , Nod Signaling Adaptor Proteins , pharmacology , physiology , Proteins , Receptors,Pattern Recognition , Rna , Rna,Viral , Switzerland , therapeutic use
Pubmed
Web of science
Création de la notice
29/01/2009 23:13
Dernière modification de la notice
03/03/2018 15:26
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