Article: article from journal or magazin.
In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance
Journal Article --- Old month value: Dec 20
The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.
*Adoptive Transfer Animals Antibodies/immunology/pharmacology Antigens, CD28/immunology Antigens, CD3/immunology CD4-Positive T-Lymphocytes/*immunology Cells, Cultured Dendritic Cells/immunology Graft Survival/immunology H-2 Antigens/immunology HLA-A2 Antigen/immunology Humans Interleukin-2/pharmacology Interleukin-2 Receptor alpha Subunit/*immunology Isoantigens/*immunology Lymphocyte Activation/drug effects/immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Peptide Fragments/immunology Skin Transplantation/immunology T-Lymphocytes, Regulatory/*immunology Transplantation Tolerance/*immunology
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