Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

Détails

ID Serval
serval:BIB_2B6BCE4AC3FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.
Périodique
Molecular Psychiatry
Auteur(s)
Berrettini W., Yuan X., Tozzi F., Song K., Francks C., Chilcoat H., Waterworth D., Muglia P., Mooser V.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
13
Numéro
4
Pages
368-373
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Résumé
Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 x 10(-5)). In a third set of European populations (n= approximately 7500) which had been genotyped for approximately 6000 SNPs in approximately 2000 genes, an allele in the same haplotype was associated with CPD (nominal P=2.6 x 10(-6)). These results (in three independent populations of European origin, totaling approximately 15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND.
Mots-clé
Adult, Aged, Alleles, Case-Control Studies, Chromosomes, Human, Pair 15/genetics, Female, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Male, Microarray Analysis/methods, Middle Aged, Nerve Tissue Proteins/genetics, Polymorphism, Single Nucleotide/genetics, Receptors, Nicotinic/genetics, Retrospective Studies, Sensitivity and Specificity, Tobacco Use Disorder/epidemiology, Tobacco Use Disorder/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2013 11:56
Dernière modification de la notice
08/05/2019 16:20
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