Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.
Details
Serval ID
serval:BIB_2A4419A0B2A2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.
Journal
Stroke
Working group(s)
Swiss SOS Study Group
Contributor(s)
Burkhardt J.K., Neidert M.C., Maldaner N., Finkenstädt S., Schöni D., Raabe A., Beck J., Mariani L., Guzman R., D'Alonzo D., Daniel R.T., Reinert M., Ferrari A., Hildebrandt G., Weyerbrock A., Corniola M.
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
49
Number
12
Pages
3081-3084
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid
hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome
measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH.
Methods—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a
tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage];
2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs
for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze
home-time differences per modified Rankin Scale category.
Results—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing
data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores
at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals,
the relationship between home-time and modified Rankin Scale was maintained.
Conclusions—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure,
discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This
measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is
particularly relevant to the patient.
hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome
measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH.
Methods—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a
tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage];
2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs
for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze
home-time differences per modified Rankin Scale category.
Results—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing
data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores
at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals,
the relationship between home-time and modified Rankin Scale was maintained.
Conclusions—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure,
discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This
measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is
particularly relevant to the patient.
Keywords
Adult, Aged, Aneurysm, Ruptured/physiopathology, Female, Humans, Independent Living/statistics & numerical data, Intracranial Aneurysm/physiopathology, Linear Models, Male, Middle Aged, Outcome Assessment (Health Care), Patient Discharge, Residence Characteristics/statistics & numerical data, Subarachnoid Hemorrhage/physiopathology, Time Factors, cerebrovascular stroke, disability evaluation, intracranial aneurysm, intracranial hemorrhages, outcome measure, subarachnoid hemorrhage
Pubmed
Web of science
Create date
15/02/2019 19:21
Last modification date
09/10/2019 6:09
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