Bone-marrow haematopoietic-stem-cell niches.

Détails

ID Serval
serval:BIB_2961220A125B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Bone-marrow haematopoietic-stem-cell niches.
Périodique
Nature Reviews. Immunology
Auteur(s)
Wilson A., Trumpp A.
ISSN
1474-1733 (Print)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2006
Volume
6
Numéro
2
Pages
93-106
Langue
anglais
Résumé
Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therapeutic potential of these cells. Here we review recent progress in characterizing the composition of the HSC bone-marrow microenvironment, known as the HSC niche. During homeostasis, HSCs, and therefore putative bone-marrow HSC niches, are located near bone surfaces or are associated with the sinusoidal endothelium. The molecular crosstalk between HSCs and the cellular constituents of these niches is thought to control the balance between HSC self-renewal and differentiation, indicating that future successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem-cell-niche unit.
Mots-clé
Animals, Bone Marrow/immunology, Cell Differentiation/immunology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/immunology, Homeostasis/immunology, Humans, Models, Immunological
Pubmed
Web of science
Création de la notice
11/04/2013 13:09
Dernière modification de la notice
20/08/2019 13:09
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