Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.

Details

Serval ID
serval:BIB_2900C83E1AC7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Journal
Virology
Author(s)
Georgel P., Jiang Z., Kunz S., Janssen E., Mols J., Hoebe K., Bahram S., Oldstone M.B., Beutler B.
ISSN
0042-6822 (Print)
ISSN-L
0042-6822
Publication state
Published
Issued date
2007
Volume
362
Number
2
Pages
304-313
Language
english
Abstract
We have previously shown that mutations of CD14 or TLR4 impair type I interferon (IFN) production and macrophage survival during infection with vesicular stomatitis virus (VSV). We now report that VSV glycoprotein G (gpG) is essential for the induction of a previously unrecognized CD14/TLR4-dependent response pathway in which the adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response. The pathway is utilized by myeloid dendritic cells (mDCs) and macrophages rather than plasmacytoid DCs. This new mode of TLR4 signal transduction, which does not stimulate NF-kappaB activation, reveals the importance of viral protein recognition by mDCs and shows that TLR4 can drive qualitatively different events within the cell in response to different ligands.
Keywords
Adaptor Proteins, Vesicular Transport/immunology, Animals, Cell Line, Cell Survival, Dendritic Cells/immunology, Female, Gene Expression Regulation, Humans, Interferon Regulatory Factor-7/biosynthesis, Interferon Type I/biosynthesis, Macrophages, Peritoneal/virology, Male, Membrane Glycoproteins/immunology, Membrane Transport Proteins/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Myelin Proteins/immunology, Myelin and Lymphocyte-Associated Proteolipid Proteins, Myeloid Differentiation Factor 88/immunology, Proteolipids/immunology, RNA, Messenger/biosynthesis, Receptors, Interleukin/immunology, Signal Transduction, Toll-Like Receptor 4/immunology, Toll-Like Receptor 4/metabolism, Vesicular stomatitis Indiana virus/immunology, Viral Envelope Proteins/immunology
Pubmed
Web of science
Open Access
Yes
Create date
17/04/2013 11:56
Last modification date
20/08/2019 13:08
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