Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis.
Virchows Archiv : An International Journal of Pathology
The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely unknown. Cytogenetic data on SFTs of the pleura are sparse. We report herein a case of a malignant SFT of the pleura where successful karyotyping was obtained from the primary and recurrent tumors. The initial karyotype showed two abnormal clones: 48, XY; +8; +8; del(9)(q22; q32)  and 46, XY, t(1;16)(q25;p12) . Culture of the recurrent tumor yielded one clone identical to the dominant clone of the initial karyotype. Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT.
Aneuploidy, Chromosome Banding, Chromosome Deletion, Chromosomes, Human, Pair 8, Fatal Outcome, Humans, Lung Neoplasms/secondary, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasms, Fibrous Tissue/genetics, Neoplasms, Fibrous Tissue/secondary, Pleural Neoplasms/genetics, Pleural Neoplasms/pathology, Quinacrine/diagnostic use, Translocation, Genetic
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