Natural history of diffuse uveal melanocytic proliferation. Case report

Détails

ID Serval
serval:BIB_273C4CBB1035
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Natural history of diffuse uveal melanocytic proliferation. Case report
Périodique
Ophthalmology
Auteur(s)
Borruat  F. X., Othenin-Girard  P., Uffer  S., Othenin-Girard  B., Regli  F., Hurlimann  J.
ISSN
0161-6420 (Print)
Statut éditorial
Publié
Date de publication
11/1992
Volume
99
Numéro
11
Pages
1698-704
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
BACKGROUND: Diffuse uveal melanocytic proliferation is a rare paraneoplastic syndrome resulting in rapid bilateral visual loss due to proliferation of benign melanocytes within the choroid and ciliary body. Most of the previously reported cases have been seen with bilateral involvement and typical ocular features. PATIENT: The authors report the case of a 61-year-old man who presented with uniocular posterior pole lesions at the level of the retinal pigment epithelium and subsequently developed the typical bilateral lesions of diffuse uveal melanocytic proliferation. His clinical course was typical, with visual disturbance preceding signs and symptoms of malignancy by 5 months. Rapid decline ensued, and he eventually died 10 months after the onset of visual symptoms. RESULTS: Results of ocular pathologic examination showed the typical choroidal thickening due to the proliferation of melanocytes and the primary tumor was found to be an undifferentiated adenocarcinoma originating in either the pancreas or the esophagus. CONCLUSIONS: The very early funduscopic and fluorescein angiographic findings of diffuse uveal melanocytic proliferation are presented as well as the evolution, ocular pathology, and possible mechanisms for its development.
Mots-clé
Cell Division Choroid Diseases/pathology Fluorescein Angiography Fundus Oculi Humans Male Melanocytes/*pathology Middle Aged Paraneoplastic Syndromes/*pathology Uveal Diseases/*pathology Visual Fields
Pubmed
Web of science
Création de la notice
28/01/2008 12:38
Dernière modification de la notice
20/08/2019 13:06
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