FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase

Details

Serval ID
serval:BIB_272E72D46A34
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase
Journal
Annals of the New York Academy of Sciences
Author(s)
Geering  K., Beguin  P., Garty  H., Karlish  S., Fuzesi  M., Horisberger  J. D., Crambert  G.
ISSN
0077-8923 (Print)
Publication state
Published
Issued date
04/2003
Volume
986
Pages
388-94
Notes
Journal Article
Review --- Old month value: Apr
Abstract
The recently defined FXYD protein family contains seven members that are small, single-span membrane proteins characterized by a signature sequence containing an FXYD motif and three other conserved amino acid residues. Until recently, the functional role of FXYD proteins was largely unknown, with the exception of the gamma subunit of Na,K-ATPase, which was shown to be a specific regulator of renal alpha1-beta1 isozymes. We have investigated whether other members of the FXYD family may have a similar role as the gamma subunit and have found that CHIF (corticosteroid hormone-induced factor, FXYD4), FXYD7, as well as phospholemman (FXYD1) specifically associate with Na,K-ATPase and preferentially with alpha1-beta isozymes in native tissues, and produce distinct effects on the transport properties of Na,K-ATPase that are adapted to the physiological demands of the tissues in which they are expressed. These results provide evidence for a unique and novel mode of regulation of Na,K-ATPase by FXYD proteins that involves a tissue-specific expression of an auxiliary subunit of distinct Na,K-ATPase isozymes.
Keywords
Amino Acid Sequence Animals Colon Conserved Sequence Intestinal Mucosa/enzymology Isoenzymes/chemistry/metabolism Kidney/*enzymology Lysosomes/enzymology Membrane Proteins/*metabolism Na(+)-K(+)-Exchanging ATPase/chemistry/*metabolism Neurons/enzymology Protein Subunits/chemistry/metabolism
Pubmed
Web of science
Create date
24/01/2008 12:28
Last modification date
20/08/2019 13:06
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