Mitochondrial regulation in pluripotent stem cells.

Details

Serval ID
serval:BIB_26314945F44A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mitochondrial regulation in pluripotent stem cells.
Journal
Cell metabolism
Author(s)
Xu X., Duan S., Yi F., Ocampo A., Liu G.H., Izpisua Belmonte J.C.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Publication state
Published
Issued date
03/09/2013
Peer-reviewed
Oui
Volume
18
Number
3
Pages
325-332
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs). While glycolytic energy production is observed at pluripotent states, an increase in mitochondrial oxidative phosphorylation is necessary for cell differentiation. Consequently, a transition from somatic mitochondrial oxidative metabolism to glycolysis seems to be required for successful reprogramming. Future research aiming to dissect the roles of mitochondria in the establishment and homeostasis of pluripotency, as well as combining cell reprogramming with gene editing technologies, may unearth novel insights into our understanding of mitochondrial diseases and aging.
Keywords
Animals, Cell Differentiation, Cellular Reprogramming, Energy Metabolism, Glycolysis, Induced Pluripotent Stem Cells/cytology, Induced Pluripotent Stem Cells/metabolism, Mitochondria/metabolism, Oxidative Phosphorylation
Pubmed
Web of science
Open Access
Yes
Create date
14/08/2018 9:38
Last modification date
20/08/2019 13:04
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