Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats.

Détails

ID Serval
serval:BIB_24257A8787C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats.
Périodique
American Journal of Physiology. Renal Physiology
Auteur(s)
Boubred F., Daniel L., Buffat C., Feuerstein J.M., Tsimaratos M., Oliver C., Dignat-George F., Lelièvre-Pégorier M., Simeoni U.
ISSN
1522-1466 (Electronic)
ISSN-L
1522-1466
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
297
Numéro
4
Pages
F943-F951
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Low birth weight is associated with an increased risk of hypertension and renal dysfunction at adulthood. Such an association has been shown to involve a reduction of nephron endowment and to be enhanced by accelerated postnatal growth in humans. However, while low-birth-weight infants often undergo catch-up growth, little is known about the long-term vascular and renal effects of accelerated postnatal growth. We surimposed early postnatal overfeeding (OF; reduction of litter size during the suckling period) to appropriate-birth-weight (NBW+OF) and intrauterine growth restriction (IUGR; IUGR+OF) pups, obtained after a maternal gestational low-protein diet. Blood pressure (systolic blood pressure; SBP) and renal function (glomerular filtration rate; GFR) were measured in young and aging offspring. Glomerulosclerosis and nephron number were determined in aging offspring (22 mo). Nephron number was reduced in both IUGR and IUGR+OF male offspring (by 24 and 26%). GFR was reduced by 40% in 12-mo-old IUGR+OF male offspring, and both NBW+OF and IUGR+OF aging male offspring had sustained hypertension (+25 mmHg) and glomerulosclerosis, while SBP and renal function were unaffected in IUGR aging offspring. Female offspring were unaffected. In conclusion, in this experimental model, early postnatal OF in the neonatal period has major long-lasting effects. Such effects are gender dependent. Reduced nephron number alone, associated with IUGR, may not be sufficient to induce long-lasting physiological alterations, and early postnatal OF acts as a "second hit." Early postnatal OF is a suitable model with which to study the long-term effects of postnatal growth in the pathogenesis of vascular disorders and renal disease.
Mots-clé
Aging/physiology, Animals, Animals, Newborn, Birth Weight, Blood Pressure, Female, Fetal Growth Retardation/pathology, Fetal Growth Retardation/physiopathology, Kidney Diseases/etiology, Kidney Diseases/pathology, Kidney Function Tests, Male, Nephrons/pathology, Overnutrition/complications, Rats, Rats, Sprague-Dawley, Sclerosis
Pubmed
Web of science
Création de la notice
21/02/2015 15:55
Dernière modification de la notice
03/03/2018 14:57
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