Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.

Détails

ID Serval
serval:BIB_23D037FD20F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Périodique
European Journal of Immunology
Auteur(s)
McCoy A.J., Koizumi Y., Toma C., Higa N., Dixit V., Taniguchi S., Tschopp J., Suzuki T.
ISSN
1521-4141[electronic], 0014-2980[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
40
Numéro
10
Pages
2797-2803
Langue
anglais
Résumé
Aeromonas hydrophila is a Gram-negative pathogen that causes serious infectious disease in humans. A. hydrophila induces apoptosis in infected macrophages, but the host proinflammatory responses triggered by macrophage death are largely unknown. Here, we demonstrate that the infection of mouse macrophages with A. hydrophila triggers the activation of caspase-1 and release of IL-1β. Caspase-1 activation was abrogated in macrophages deficient in Nod-like receptor family, pyrin domain containing 3 (NLRP3) and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), but not NLR family, CARD domain containing 4 (NLRC4). The activation of the NLRP3 inflammasome was mediated by three cytotoxins (aerolysin, hemolysin and multifunctional repeat-in-toxin) produced by A. hydrophila. Our results indicated that the NLRP3 inflammasome senses A. hydrophila infection through the action of bacterial cytotoxins.
Mots-clé
Aeromonas, Caspase-1, Nod-like receptor
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/09/2010 16:16
Dernière modification de la notice
08/05/2019 15:48
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