Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.

Details

Serval ID
serval:BIB_23D037FD20F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Journal
European Journal of Immunology
Author(s)
McCoy A.J., Koizumi Y., Toma C., Higa N., Dixit V., Taniguchi S., Tschopp J., Suzuki T.
ISSN
1521-4141[electronic], 0014-2980[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
40
Number
10
Pages
2797-2803
Language
english
Abstract
Aeromonas hydrophila is a Gram-negative pathogen that causes serious infectious disease in humans. A. hydrophila induces apoptosis in infected macrophages, but the host proinflammatory responses triggered by macrophage death are largely unknown. Here, we demonstrate that the infection of mouse macrophages with A. hydrophila triggers the activation of caspase-1 and release of IL-1β. Caspase-1 activation was abrogated in macrophages deficient in Nod-like receptor family, pyrin domain containing 3 (NLRP3) and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), but not NLR family, CARD domain containing 4 (NLRC4). The activation of the NLRP3 inflammasome was mediated by three cytotoxins (aerolysin, hemolysin and multifunctional repeat-in-toxin) produced by A. hydrophila. Our results indicated that the NLRP3 inflammasome senses A. hydrophila infection through the action of bacterial cytotoxins.
Keywords
Aeromonas, Caspase-1, Nod-like receptor
Pubmed
Web of science
Open Access
Yes
Create date
07/09/2010 15:16
Last modification date
20/08/2019 13:01
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