Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore
Details
Serval ID
serval:BIB_23C304437D0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804 (Print)
Publication state
Published
Issued date
08/1999
Volume
43
Number
8
Pages
2087-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Genotypic analysis of resistance to isoniazid (INH) in Mycobacterium tuberculosis is complex due to the various genes potentially involved. Mutations in ketoacyl acyl carrier protein synthase (encoded by kasA) were present in 16 of 160 (10%) INH-resistant isolates (R121K [n = 1], G269S [n = 3], G312S [n = 11], G387D [n = 1]). However, G312S was also present in 6 of 32 (19%) susceptible strains. kasA analysis contributed marginally to the performance of INH genotypic testing in Singapore. The significance of kasA polymorphisms in INH resistance should be carefully established.
Keywords
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*genetics
Antitubercular Agents/*pharmacology
Drug Resistance, Microbial/genetics
Genotype
Isoniazid/*pharmacology
Mutation
Mycobacterium tuberculosis/*drug effects/*genetics
Singapore
Pubmed
Web of science
Create date
25/01/2008 14:46
Last modification date
20/08/2019 13:01