Telomerase: biochemical considerations for enzyme and substrate.

Details

Serval ID
serval:BIB_23589
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Telomerase: biochemical considerations for enzyme and substrate.
Journal
Trends in Biochemical Sciences
Author(s)
Kelleher C., Teixeira M.T., Förstemann K., Lingner J.
ISSN
0968-0004
Publication state
Published
Issued date
2002
Volume
27
Number
11
Pages
572-579
Language
english
Abstract
Telomerase extends chromosome ends by iterative reverse transcription of its RNA template. Following the addition of each telomeric repeat, the RNA template and the telomeric substrate reset their relative position in the active site provided by the telomerase reverse transcriptase (TERT). This step might require the formation of guanine-rich secondary structures in the nascent product. Results from numerous studies begin to delineate TERT sub-domains that orchestrate these events and support the model of cooperative action between distinct active sites within telomerase multimers. Natural telomere substrates are protein-DNA complexes that show an asymmetry between the two ends of a chromosome, possibly reflecting their differential mode of replication.
Keywords
Animals, Binding Sites, DNA-Binding Proteins, Humans, RNA/genetics, RNA/metabolism, Saccharomyces cerevisiae/enzymology, Saccharomyces cerevisiae/genetics, Substrate Specificity, Telomerase/genetics, Telomerase/metabolism
Pubmed
Web of science
Create date
19/11/2007 12:19
Last modification date
20/08/2019 13:01
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