A role for CD147 in thymic development.

Détails

ID Serval
serval:BIB_23513
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A role for CD147 in thymic development.
Périodique
Journal of Immunology
Auteur(s)
Renno T., Wilson A., Dunkel C., Coste I., Maisnier-Patin K., Benoit de Coignac A., Aubry J.P., Lees R.K., Bonnefoy J.Y., MacDonald H.R., Gauchat J.F.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
168
Numéro
10
Pages
4946-4950
Langue
anglais
Résumé
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
Mots-clé
Amino Acid Sequence, Animals, Antibodies, Monoclonal/metabolism, Antigens, CD, Antigens, CD147, Antigens, Neoplasm, Antigens, Surface, Avian Proteins, Base Sequence, Binding Sites, Antibody/genetics, Blood Proteins, Cell Cycle/genetics, Cell Cycle/immunology, Cell Differentiation/genetics, Cell Differentiation/immunology, Cell Line, Cloning, Molecular, Female, Fetus, Humans, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Organ Culture Techniques, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, Thymus Gland/cytology, Thymus Gland/embryology, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
19/11/2007 12:19
Dernière modification de la notice
20/08/2019 13:00
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