Article: article from journal or magazin.
A role for CD147 in thymic development.
Journal of Immunology
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
Amino Acid Sequence, Animals, Antibodies, Monoclonal/metabolism, Antigens, CD, Antigens, CD147, Antigens, Neoplasm, Antigens, Surface, Avian Proteins, Base Sequence, Binding Sites, Antibody/genetics, Blood Proteins, Cell Cycle/genetics, Cell Cycle/immunology, Cell Differentiation/genetics, Cell Differentiation/immunology, Cell Line, Cloning, Molecular, Female, Fetus, Humans, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Organ Culture Techniques, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, Thymus Gland/cytology, Thymus Gland/embryology, Tumor Cells, Cultured
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