A role for CD147 in thymic development.
Details
Serval ID
serval:BIB_23513
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A role for CD147 in thymic development.
Journal
Journal of Immunology
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
168
Number
10
Pages
4946-4950
Language
english
Abstract
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
Keywords
Amino Acid Sequence, Animals, Antibodies, Monoclonal/metabolism, Antigens, CD, Antigens, CD147, Antigens, Neoplasm, Antigens, Surface, Avian Proteins, Base Sequence, Binding Sites, Antibody/genetics, Blood Proteins, Cell Cycle/genetics, Cell Cycle/immunology, Cell Differentiation/genetics, Cell Differentiation/immunology, Cell Line, Cloning, Molecular, Female, Fetus, Humans, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Organ Culture Techniques, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, Thymus Gland/cytology, Thymus Gland/embryology, Tumor Cells, Cultured
OAI-PMH
Pubmed
Web of science
Create date
19/11/2007 13:19
Last modification date
20/08/2019 14:00
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