Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock.

Details

Serval ID
serval:BIB_23457A739944
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock.
Journal
Journal of inflammation
Author(s)
Calandra T., Bucala R.
ISSN
1078-7852
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
47
Number
1-2
Pages
39-51
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review - Publication Status: ppublish
Abstract
Recent studies have led to the discovery of a mediator that acts as an endogenous counter-regulator of glucocorticoid action within the immune system. Isolated as a product of anterior pituitary cells, this protein was found to have the sequence of macrophage migration inhibitory factor (MIF), one of the first cytokine activities to be described. Macrophages and T cells release MIF in response both to various inflammatory stimuli and upon incubation with low concentrations of glucocorticoids. The glucocorticoid-induced secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentrations. Once secreted, MIF "overrides" the anti-inflammatory and immunosuppressive effects of steroids on macrophage and T-cell cytokine production. The physiological role of MIF thus appears to be to counter-balance steroid inhibition of the inflammatory response. Anti-MIF antibodies fully protect animals from experimentally induced gram-negative or gram-positive septic shock, an effect that may be the result of the increased anti-inflammatory effects of glucocorticoids after neutralization of endogenous MIF. Anti-MIF therapeutic strategies are presently under development and may prove to be a means to modulate cytokine production in septic shock as well as in other inflammatory disease states.
Keywords
Adjuvants, Immunologic, Amino Acid Sequence, Animals, Base Sequence, Glucocorticoids, Humans, Macrophage Migration-Inhibitory Factors, Molecular Sequence Data, Receptors, Glucocorticoid, Shock, Septic
Pubmed
Web of science
Create date
25/01/2008 13:28
Last modification date
20/08/2019 13:00
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