Estrogen and exercise may be related to body fat distribution and leptin in young women.
Details
Serval ID
serval:BIB_22E05836A1E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Estrogen and exercise may be related to body fat distribution and leptin in young women.
Journal
Fertility and Sterility
ISSN
1556-5653 (Electronic)
ISSN-L
0015-0282
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
86
Number
3
Pages
694-699
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: To evaluate the effects of estrogen deficiency and exercise on body composition and leptin in young women.
DESIGN: Cross-sectional clinical study.
SETTING: Volunteers in an academic research environment.
PATIENT(S): Three age- and body mass index-matched groups: normal-weight women with exercise-associated amenorrhea, regularly menstruating exercising control women, and regularly menstruating normally active control women.
INTERVENTION(S): Collection of blood samples and measurement of body fat and regional fat distribution by dual-energy x-ray absorptiometry.
MAIN OUTCOME MEASURE(S): Central fat accumulation (i.e., ratio of trunk to extremity fat) and serum concentrations of E(2) and leptin.
RESULT(S): In both regularly menstruating control groups, but not in the amenorrheic women, there was a negative correlation between the serum E(2) concentrations and the trunk-to-extremity fat ratio (r = -0.4), independent of age, exercise, body fat, and serum T concentrations. In all women, E(2) concentrations were positively and exercise inversely correlated to leptin concentrations, independent of body fat.
CONCLUSION(S): Estradiol level is inversely associated with central fat accumulation only in women with regular menstrual cycles. In all young premenopausal subjects, estrogen secretion influences leptin concentrations independently of body fat.
DESIGN: Cross-sectional clinical study.
SETTING: Volunteers in an academic research environment.
PATIENT(S): Three age- and body mass index-matched groups: normal-weight women with exercise-associated amenorrhea, regularly menstruating exercising control women, and regularly menstruating normally active control women.
INTERVENTION(S): Collection of blood samples and measurement of body fat and regional fat distribution by dual-energy x-ray absorptiometry.
MAIN OUTCOME MEASURE(S): Central fat accumulation (i.e., ratio of trunk to extremity fat) and serum concentrations of E(2) and leptin.
RESULT(S): In both regularly menstruating control groups, but not in the amenorrheic women, there was a negative correlation between the serum E(2) concentrations and the trunk-to-extremity fat ratio (r = -0.4), independent of age, exercise, body fat, and serum T concentrations. In all women, E(2) concentrations were positively and exercise inversely correlated to leptin concentrations, independent of body fat.
CONCLUSION(S): Estradiol level is inversely associated with central fat accumulation only in women with regular menstrual cycles. In all young premenopausal subjects, estrogen secretion influences leptin concentrations independently of body fat.
Keywords
Adipose Tissue/metabolism, Adult, Amenorrhea/metabolism, Body Composition, Estrogens/blood, Exercise, Female, Humans, Leptin/metabolism, Statistics as Topic, Tissue Distribution
Pubmed
Web of science
Create date
15/02/2008 18:19
Last modification date
20/08/2019 14:00
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